Wednesday, October 1, 2025

IBM and AMD Partner with Zyphra for GenAI Infrastructure

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IBM and AMD have entered a multi-year partnership with Zyphra, an open-source AI research and product company headquartered in San Francisco, California. As part of the agreement, IBM will provide Zyphra with a large cluster of AMD Instinct™ MI300X GPUs on IBM Cloud. This infrastructure is designed to support the training of frontier multimodal foundation models and is expected to rank among the most advanced generative AI training capabilities deployed to date, powered entirely by an AMD technology stack integrated on IBM Cloud. 

Zyphra, which recently secured Series A funding at a $1B valuation, is building an open-source superintelligence lab aimed at driving breakthroughs in neural network design, long-term memory, and continual learning.

Zyphra becomes an initial receiver of the dedicated large-scale training cluster on IBM Cloud powered by AMD Instinct MI300X GPUs, along with AMD Pensando™ Pollara 400 AI NICs and AMD Pensando Ortano DPUs. Zyphra intends to use the infrastructure to train multimodal foundation models spanning language, vision, and audio, which will support Maia, its general-purpose superagent created to enhance productivity for enterprise knowledge workers. 

“This collaboration marks the first time AMD’s full-stack training platform—spanning compute through networking—has been successfully integrated and scaled on IBM Cloud, and Zyphra is honored to lead the way in developing frontier models with AMD silicon on IBM Cloud,” said Krithik Puthalath, CEO and Chairman of Zyphra. “We’re excited to partner with IBM and AMD to power the next era of open-source, enterprise superintelligence.”

IBM and AMD emphasized the significance of combining their expertise to enable this initiative. “Scaling AI workloads faster and more efficiently is a key differentiator in achieving ROI for established enterprises and emerging companies alike,” said Alan Peacock, GM of IBM Cloud. “We are delighted to support Zyphra’s strategic roadmap as we collaborate with AMD to deliver scalable, economical AI infrastructure that can accelerate Zyphra’s model training.” 

Philip Guido, EVP and Chief Commercial Officer at AMD, added, “The IBM and AMD collaboration delivers innovation at the speed and scale clients demand, representing a new standard in AI infrastructure. By combining IBM enterprise cloud expertise with AMD leadership in high-performance computing and AI acceleration, we are supporting Zyphra’s pioneering work in multimodal and inference-efficient AI, enabling organizations everywhere to build smarter businesses and unlock AI solutions that drive real-world outcomes.” 

Both companies are continuing to push the boundaries of performance and efficiency in AI infrastructure, with future plans that extend to quantum-centric supercomputing, combining IBM’s quantum technologies with AMD’s strengths in HPC and AI accelerators.

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